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Proposed model for EP2-mediated signaling. EP2 stimulation by ligand binding leads to Gαs activation and dissociation, which then caused AC activation, cAMP production and PKA activation. EP2 ligand binding also causes EP2 association with β-arrestin1 and Src leading to Src activation. Activated Src then activates EGFR leading the subsequent activation of H-Ras, ERK1/2 and AKT.
