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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Mol Carcinog. 2009 Sep;48(9):853–861. doi: 10.1002/mc.20531

Fig 5.

Fig 5

Immunohistochemical expression of p16 in (A) normal, (B) dysplastic and (C) neoplastic regions of tongues from 4NQO-treated L2-D1 mice. Note that the expression of p16 is retained in the dysplastic and neoplastic lesions. Immunohistochemical expression of Cox2 in (D) normal, (E) dysplastic regions of the tongue and (F) SCC lesion from the esophagus. Immunohistochemical expression of E-cadherin (G—I) in a SCC lesion on the tongue. Panel H shows a magnified region of section indicated in (G) and demonstrates patchy loss of E-cadherin. Panel I shows that expression of E-cadherin in the islands of neoplastic epithelium.