Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibitory properties of synthetic tanikolide dimers to SIRT1 and SIRT2.
| SIRT1 | SIRT2 | |
|---|---|---|
| Compound | IC50 ± SE (µM) | IC50 ± SE (µM) |
| (R,S) tanikolide dimer (4) | 28.8 ± 4.3 | 2.4 ± 0.2 |
| (R,R) tanikolide dimer (5) | 36.4 ± 8.1 | 3.3 ± 0.2 |
| (S,S) tanikolide dimer (ent-5) | 34.5 ± 3.5 | 3.1 ± 0.3 |
