Table 3.
SIRT1 | SIRT2 | |
---|---|---|
Compound | IC50 ± SE (µM) | IC50 ± SE (µM) |
(R,S) tanikolide dimer (4) | 28.8 ± 4.3 | 2.4 ± 0.2 |
(R,R) tanikolide dimer (5) | 36.4 ± 8.1 | 3.3 ± 0.2 |
(S,S) tanikolide dimer (ent-5) | 34.5 ± 3.5 | 3.1 ± 0.3 |
SIRT1 | SIRT2 | |
---|---|---|
Compound | IC50 ± SE (µM) | IC50 ± SE (µM) |
(R,S) tanikolide dimer (4) | 28.8 ± 4.3 | 2.4 ± 0.2 |
(R,R) tanikolide dimer (5) | 36.4 ± 8.1 | 3.3 ± 0.2 |
(S,S) tanikolide dimer (ent-5) | 34.5 ± 3.5 | 3.1 ± 0.3 |