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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Gastroenterology. 2009 Mar 26;137(3):1051–1060.e3. doi: 10.1053/j.gastro.2009.03.040

Figure 5.

Figure 5

Phosphorylation status of MLC20 affects myosin II transcriptional activity on ICAM-1. (A) ML-7 (5 μM) induced and MCLR (5 nM) suppressed ICAM-1 promoter activity (n=3), *p<0.05 vs control. pT18/S19MLC20 was monitered by immunostaining (top panel). (B) Twenty-four hour incubation with ML-7 increased ICAM-1 protein expression in muscularis externa of rat distal colon. (C) Intraperitoneal administration of ML-7(1 mg/kg) in naïve intact rats induced ICAM-1 expression in the muscularis externa of the distal colon after 24 hours.