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. 2009 Sep 11;4(9):e6971. doi: 10.1371/journal.pone.0006971

Figure 1. Transcripts differentially regulated in Dgcr8 KO relative to WT and Dicer KO ES cells.

Figure 1

The sets of genes differentially up- and down- regulated in Dgcr8 KO relative to Dicer KO and WT ES cells were determined based on a cutoff of FDR <5%. Data are represented as a mean of 3 biological replicates of WT, Dgcr8 KO and Dicer KO arrays. Transcripts positive for EvoFold hairpin predictions and transcripts with 5 or more small RNAs mapping to their exons are shown (see legend). Arrow points to Dgcr8 expression levels, which, as expected, is down in Dgcr8 KO (exon 3 deletion results in premature termination codon and, hence, non-sense mediated RNA decay [33].