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Diverse ts-mutant proteins expressed in multiple tissues lose functionality with age. Percentage of age-synchronized animals expressing WT (squares) or ts (triangles): (A) ras (let-60), (B) gas-1, (C) acetylcholine receptor (unc-63), or (D) perlecan (unc-52) showing (A) osmoregulation (Osm), (B) EtOH sensitivity, (C) levamisole resistance, or (D) paralysis phenotypes. Data are mean ± SD, >45 animals per data point.
