. Author manuscript; available in PMC: 2009 Sep 2.

Published in final edited form as: Org Biomol Chem. 2008 Oct 30;7(1):76–84. doi: 10.1039/b814682a

Table 3.

Dissociation constants (K_d ± std. error) and stoichiometries (n) of compounds 7-21 with the Htelo, c-kit1, c-kit2 and N-ras quadruplexes, determined by surface plasmon resonance

	Htelo		c-kit1		c-kit2		N-ras
Compound	K_d/nM	n	K_d/nM	n	K_d/nM	n	K_d/nM	n
7	770 ± 80	1.2	^a	^a	800 ± 100	1.3	440 ± 70	0.7
8	250 ± 40	2.2	^a	^a	290 ± 40	2.0	240 ± 40	1.5
9	380 ± 50	2.3	^a	^a	400 ± 50	1.9	460 ± 70	1.6
10	140 ± 60	0.9	25 ± 8	0.4	120 ± 40	0.6	129 ± 3	0.7
11	50 ± 10	1.1	50 ± 20	0.9	130 ± 50	1.3	60 ± 40	0.6
12	28 ± 5	0.8	138 ± 5	1.3	50 ± 10	0.7	21 ± 2	0.8
13	38 ± 9	0.7	37 ± 7	0.8	37 ± 7	0.7	16 ± 3	0.8
14	22 ± 4	1.2	50 ± 20	1.2	40 ± 10	1.2	4 ± 1	0.5
15	23 ± 4	1.0	90 ± 10	1.3	40 ± 10	1.1	7 ± 1	0.8
16	20 ± 8	0.4	49 ± 9	0.4	60 ± 30	0.4	69.3 ± 0.8	0.9
17	25 ± 3	0.8	40 ± 10	0.7	50 ± 10	0.9	17 ± 5	0.6
18	19 ± 3	0.7	35 ± 8	0.6	40 ± 10	0.7	5 ± 1	0.5
19	30 ± 3	0.6	37 ± 3	0.6	40 ± 20	0.6	29 ± 2	1.1
20	13 ± 2	0.8	33 ± 6	0.8	29 ± 9	1.0	3.9 ± 0.8	0.6
21	17 ± 2	0.8	50 ± 10	0.8	30 ± 10	0.9	4.4 ± 0.9	0.6

Not determined.