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. Author manuscript; available in PMC: 2009 Sep 2.
Published in final edited form as: J Mol Biol. 2007 Jun 4;371(5):1219–1237. doi: 10.1016/j.jmb.2007.05.093

Scheme 1.

Scheme 1

Conditions:(i) Di-tert-butyl dicarbonate, DMAP, Et3N, CH2Cl2. (ii) LHDMS, THF, −78 °C, and then ArCH2Br. (iii) 2.5 LiOH, THF. (iv) CF3COOH, CH2Cl2, rt. (v) LiBH4, THF.