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. Author manuscript; available in PMC: 2009 Sep 2.
Published in final edited form as: J Biol Chem. 2007 Nov 27;283(5):2586–2594. doi: 10.1074/jbc.M707154200

Figure 5. Predicted zfs1 TZF domain interaction with an ARE.

Figure 5

A, shown is the predicted structure of the zfs1 TZF domain complexed with UUAUUUAUU. Amino acids identical to human TTP are highlighted in green or blue, and represent primarily the ARE binding residues (variable residues are yellow). Select conserved residues (white text labels) include the aromatic residues known to form stacking interactions (13) and the Arg-384 residue of the C-terminal zinc finger. B, shows selected residues from the zfs1 TZF domain and their potential interactions with A7 of the UUAUUUAUU nonamer in proximity to the zinc binding core. This picture illustrates the possible interactions between residues of the N-terminal zinc-finger, Arg-384 from the C-terminal zinc-finger and the A7 nucleotide. Distances between functional group core atoms are shown.