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. 2009 Sep 18;5(9):e1000587. doi: 10.1371/journal.ppat.1000587

Figure 6. Identification of a minimal hPIV3-C region interacting with GRB2.

Figure 6

Fragments of hPIV3-C were generated and tested for their ability to interact with GRB2 following the procedure described in Figure 5A. (A) The first iteration identified a GRB2 binding region of 124 AA. After two (B), three (C) and four additional rounds (D), this domain was finally reduced to a minimal GRB2 binding motif of 99 AA. This binding domain, encompassing position 97 to 195, is contained in the STAT1 binding region of hPIV3-C previously identified in Figure 5.