Table 1.
Prions of mammals, yeast and the filamentous fungus Podospora anserina
| Organism | Prion | Protein | Normal function | Prion manifestation |
| Mammals | TSEs | PrP | Not known | Transmissible spongiform encephalopathy |
| Saccharomyces cerevisiae | [URE3] | Ure2 | Nitrogen catabolite repression | Derepression of nitrogen catabolism enzymes and transporters |
| [PSI+] | Sup35 | Translation termination | Read-through of stop codons | |
| [PIN+] | Rnq1 | Not known | Rare seeding of [PSI+], other prions | |
| [SWI+] | Swi1 | Chromatin remodeling | Poor growth on glycerol, raffinose, galactose | |
| [MCA] | Mca1 | Metacaspase (suspected function in apoptosis) | Unknown | |
| [OCT+] | Cyc8 | Repression of CYC7 and other genes | Derepression of transcription | |
| [MOT3+] | Mot3 | Transcription factor | Cell-wall changes | |
| Podospora anserina | [Het-s] | HET-s | Heterokaryon incompatibility; meiotic drive (as a prion) | Heterokaryon incompatibility; meiotic drive (as a prion) |