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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2008 Sep 25;28(12):2202–2208. doi: 10.1161/ATVBAHA.108.172320

Figure 4. Pharmacological inhibition of CatK reduces mouse body weight gain and increases tissue fibronectin.

Figure 4

A. Female C57BL/6 mice started consuming a HFD and receiving K4b (1 mg/kg/day) or DMSO at age 6 weeks (indicated). B. Fibronectin immunostaining in muscle and fat paraffin sections from K4b-treated C57BL/6 mice. C. Inhibition of CatK reduces body weight gain in ob/ob mice. D. Fibronectin immunostaining in fat and muscle from vehicle- and K4b-treated ob/ob mice.