Table 2.
Age- and gender- and multivariable-adjusted least square means and SEMs of arterial stiffness measures by eGFRcrea-based CKD statusa
Measures | No CKD (eGFRcrea ≥60 ml/min/1.73 m2) (n = 2501) | CKD (eGFRcrea <60 ml/min/1.73 m2) (n = 181) | P Value |
---|---|---|---|
Carotid-femoral PWV (m/s) | |||
Age and gender | 9.9 ± 0.1 | 10.6 ± 0.2 | 0.11 |
Multivariableb | 9.9 ± 0.1 | 10.5 ± 0.2 | 0.24 |
Forward pressure wave amplitude (mmHg) | |||
Age and gender | 40.6 ± 0.2 | 41.3 ± 0.9 | 0.48 |
Multivariableb | 41.0 ± 0.2 | 41.8 ± 0.8 | 0.79 |
Central pulse pressure (mmHg) | |||
Age and gender | 50.7 ± 0.3 | 52.1 ± 1.1 | 0.23 |
Multivariableb | 50.9 ± 0.3 | 52.0 ± 1.0 | 0.34 |
Augmentation pressure (mmHg) | |||
Age and gender | 8.7 ± 0.1 | 9.4 ± 0.6 | 0.26 |
Multivariableb | 8.6 ± 0.1 | 9.3 ± 0.5 | 0.15 |
Augmentation index (%) | |||
Age and gender | 15.4 ± 0.2 | 15.0 ± 0.9 | 0.61 |
Multivariableb | 15.1 ± 0.2 | 14.8 ± 0.8 | 0.77 |
Mean arterial pressure (mmHg) | |||
Age and gender | 91.8 ± 0.2 | 91.4 ± 0.9 | 0.73 |
Multivariableb | 91.6 ± 0.2 | 90.6 ± 0.9 | 0.32 |
aeGFRcrea, estimated GFR by creatinine-based Modification of Diet in Renal Disease study equation; PWV, pulse wave velocity.
bMultivariable models include: age, gender, Omni cohort status, body mass index, heart rate, mean arterial pressure (for models other than mean arterial pressure), diabetes, fasting blood glucose, total/high density lipoprotein cholesterol, lipid lowering medication use, triglycerides, hypertension treatment, hormone replacement therapy in women, current smoking status and prevalent cardiovascular disease.