Figure 2. Electroconvulsive threshold variation in 23 mouse strains.
The median thresholds (mA ± 95% CI) to clonic forebrain seizures are shown. Thresholds for I/LnJ, P/J, and MRL/MpJ have not been previously published. The remaining values were recalculated and re-plotted from previous studies 13, 33, 35; the new data were collected and analyzed as described in those studies. For simplicity of presentation, only female data are shown, but the relative strain thresholds are similar for male. A four mA range of median seizure threshold amongst the different inbred strains is suggestive of a very appreciable amount of genetic variation.