Table 2.
Summary of statin- and lipid-related genes.
| Gene (HUGO) |
Gene name | Accession number1 |
Percent sequenced2 |
N, common SNPs3 |
N, common haplotypes3 |
Interaction p-value | Main effects p-value | ||
|---|---|---|---|---|---|---|---|---|---|
| MI | Stroke | MI | Stroke | ||||||
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | AY910577 | 43 | 13 | 8 | 0.19 | 0.85 | 0.13 | 0.29 |
| CETP | Cholesteryl ester transfer protein | AY422211 | 97 | 12 | 5 | 0.09 | 0.75 | 0.084 | 0.624 |
| HMGCR | 3-hydroxy-3- methylglutaryl- Coenzyme A reductase | AY321356 | 99 | 5 | 5 | 0.94 | 0.46 | 0.96 | 0.60 |
| NOS3 | Nitric oxide synthase3 (endothelial cell) | AF519768 | 93 | 11 | 8 | 0.46 | 0.60 | 0.99 | 0.88 |
| LDLR | Low density lipoprotein receptor | AY324609 | 87 | 11 | 5 | 0.38 | 0.30 | 0.85 | 0.44 |
| LIPC | Lipase, hepatic | N/A | N/A | 30 | 0 | 0.24 | 0.23 | 0.026 | 0.89 |
| Total | --- | --- | 82 | 31 | --- | --- | --- | --- | |
1
Accession numbers are those referenced in Entrez Gene.
2
Refers to percent of mRNA transcript sequenced.
3
Common = frequency ≥ 5% in any case or control group.
4
From Enquobahrie, et al., 2007.