Table 1. Demographic and clinical characteristics of the study group.
| Number of patients (n=51) | |
|---|---|
| Age (years) | |
| At cancer diagnosis | 26 (14–42) |
| At current examination | 50 (35–63) |
| Observation time | 22 (11–27) |
| Females; n (%) | 34 (67) |
| Cancer stage; n (%) | |
| Stages I and II | 40 (78) |
| Stages III and IV | 11 (22) |
| Relapses; n (%) | 6 (12) |
| Radiotherapy | |
| Radiation dose (Gy) | 40.0 (27.0–44.0) |
| Mantle field; n (%) | 43 (84) |
| Mediastinal field only; n (%) | 8 (16) |
| Chemotherapy | |
| Chemotherapy; n (%)a | 36 (71) |
| Received anthracyclines; n (%) | 28 (55) |
| Dose of adriamycin (mg)a | 320 (110–480) |
| ChlVPP/ABOD; n (%) | 23 (45) |
| ChlVPP only; n (%) | 5 (10) |
| ABOD only; n (%) | 4 (8) |
| ChlVPP/EBVP; n (%)b | 1 (2) |
| Other regimes; n (%) | 3 (6) |
| Current smoker; n (%) | 14 (27) |
| Self-reported comorbidities; n (%) | |
| History of hypothyroidism | 34 (67) |
| History of hypercholesterolaemia | 10 (20) |
| Diabetes | 1 (4) |
| Cardiovascular disease | 15 (29) |
| Coronary disease | 9 (18) |
| Stroke or TIA | 3 (6) |
| Valvular surgery | 3 (6) |
| Clinical findings | |
| Systolic blood pressure (mmHg) | 123 (85–156) |
| Diastolic blood pressure (mmHg) | 72 (52–95) |
| Hypertension; n (%)c | 13 (25) |
| Body mass index (kg/m2) | 24.0 (17.4–34.2) |
| Blood samples | |
| Cholesterol (mmol l−1) | 5.3 (3.4–7.0) |
| HDL cholesterol (mmol l−1) | 1.3 (0.8–2.3) |
| LDL-cholesterol (mmol l−1) | 3.6 (1.8–4.7) |
| Triglycerides (mmol l−1) | 1.1 (0.6–3.7) |
| CRP (mg l−1) | 2.35 (0.20–43) |
| proBNP (pmol l−1) | 21.0 (3.7–201) |
Medians and ranges are given for all continuous parameters.
ChlVPP=chlorambucil, vinblastin, procarbazine, prednisolon; ABOD=adriamycin, bleomycin, vincristin, dacarbazine; EBVP=epirubicin, bleomycin, vinblastin, prednisolon.
a
Including chemotherapy for relapses.
b
Epirubicin was given to one patient at a total dose of 720 mg.
c
Hypertension: systolic blood pressure ⩾140 mmHg or a diastolic blood pressure ⩾90 mmHg or the use of antihypertensive medication in order to lower blood pressure.