Table 4. Multiple linear regression analysis of factors involved in changes of left ventricular function from ECHO 1993 to ECHO 2005.

	Treatment with anthracyclines (yes/no)		Age at ECHO 2005		Cardiovascular disease (yes/no)		Aortic stenosis (yes/no)
Echocardiographic parameters	β (95 % CI)	P value	β (95 % CI)	P value	β (95 % CI)	P value	β (95 % CI)	P value
LVEDD	0.051 (−0.001 to 0.102)	0.053	0.003 (−0.001 to 0.007)	0.15	0.018 (−0.043 to 0.078)	0.56	0.060 (0.009 to 0.111)	0.021
LVESD	0.089 (0.006 to 0.172)	0.036	0.005 (−0.001 to 0.012)	0.091	0.087 (−0.011 to 0.185)	0.082	0.079 (−0.003 to 0.161)	0.058
IVSd	−0.161 (−0.297 to −0.025)	0.021	−0.010 (−0.021 to 0.000)	0.046	0.040 (−0.121 to 0.201)	0.62	0.004 (−0.130 to 0.139)	0.95
LVPW	−0.178 (−0.325 to −0.031)	0.019	−0.005 (−0.016 to 0.006)	0.35	−0.010 (−0.185 to 0.164)	0.91	0.020 (−0.125 to 0.166)	0.78
LV-SF	−0.058 (−0.176 to 0.060)	0.33	−0.004 (−0.013 to 0.005)	0.38	−0.168 (−0.308 to −0.028)	0.020	−0.008 (−0.125 to 0.109)	0.89
CI	0.018 (−0.156 to 0.191)	0.84	−0.014 (−0.028 to −0.001)	0.035	−0.154 (−0.359 to 0.051)	0.14	0.056 (−0.116 to 0.227)	0.52

LVEDD=left ventricular end diastolic diameter; LVESD=left ventricular end systolic diameter; IVSd=interventricular septum thickness; LVPW=left ventricular posterior wall; CI=cardiac index; LV-FS=left ventricular shortening fraction.