Table 2. Late effects, vulnerability, health-related QOL (SF-12v2) scores and preference for follow-up.
| Breast (N=75) | Haematology (N=131) | Germ cell (N=103) | Total (N=309) | ||
|---|---|---|---|---|---|
| Late effectsa range 0–18 | Total mean (CI) | 1.9 (1.5–2.4) | 1.9 (1.6–2.2) | 1.1 (0.7–1.5) | 1.6 (1.4–1.9) |
| Most common late effects % (n/N) | First | Weight gain | Infertility | Testicular/ ovarian damage | |
| 32.0 (24/75) | 28.2 (37/131) | 26.2 (27/103) | |||
| Second | Lymphoedema | Thyroid damage | Infertility | ||
| 30.7 (23/75) | 21.4 (28/131) | 12.6 (13/103) | |||
| Third | Mood swings | Chronic fatigue | Hearing loss | ||
| 29.3 (22/75) | 17.6 (23/131) | 10.7 (11/103) | |||
| Vulnerability to late effectsb range 1–5 | Mean (CI) | 2.6 (2.4–2.7) | 2.7 (2.6–2.8) | 2.4 (2.3–2.5) | 2.6 (2.5–2.6) |
| Health-related QOLc | Physical component summary (CI) | 52.8 (50.9–54.7) | 52.1 (50.6–53.7) | 53.7 (52.0–55.4) | 52.8 (51.8–53.8) |
| Mental component summary (CI) | 45.3 (42.8–47.8) | 48.7 (47.1–50.3) | 51.0 (49.3–52.7) | 48.6 (47.5–49.7) | |
| Breast (N=71) | Haematology (N=102) | Germ cell (N=82) | Total (N=255) | ||
| Follow-up preferences mean (CI) | Consultant led | 16.4 (15.8–17.0) | 17.2 (16.7–17.7) | 17.0 (16.4–17.6) | 16.9 (16.6–17.2) |
| Range 4–20 | Nurse led | 12.9 (12.0–13.9) | 13.7 (13.0–14.5) | 13.4 (12.6–14.2) | 13.4 (12.9–13.9) |
| Telephone/ questionnaire | 10.0 (8.9–11.0) | 10.2 (9.3–11.1) | 11.3 (10.4–12.2) | 10.5 (10.0–11.0) | |
| GP based | 9.6 (8.5–10.6) | 9.4 (8.5–10.2) | 9.8 (8.9–10.8) | 9.6 (9.0–10.1) |
CI=confidence interval; GP=general practitioner; MCS=Mental Component Summary; PCS=Physical Component Summary; QOL=quality of life.
a
Means adjusted for age, germ cell <breast (P<0.05) and haematology (P=0.01)
b
Means adjusted for age, germ cell <haematology (P<0.05).
c
The PCS and MCS are scaled to have a mean score of 50 and s.d. 10 in line with the reference population.