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. 2009 Aug 11;101(4):637–644. doi: 10.1038/sj.bjc.6605190

Figure 2.

Figure 2

Effect of AP-2α over expression on tumour growth and cell cycle. (A) In vivo tumour growth of mock CAPAN-1 cells (C5 control clone), and of two clones overexpressing AP-2α s.c. xenografted in athymic female nude mice (n=6 per group). Tumours were measured every 3–6 days and tumour volume was calculated (see Materials and Methods section for further details). Data are shown as mean (points)±s.d. (error bars). *, P<0.05; **, P<0.01; #, P<0.001. (B) Expression levels of regulators of the cell cycle were evaluated by western blotting in control C5, α42 and α27 clones. Bands were quantified by densitometry and a ratio (specific protein to β-actin) was calculated to evaluate differences between mock cells and the clones. Ratio values are indicated under each panel.