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. 2009 Aug 11;101(4):691–698. doi: 10.1038/sj.bjc.6605202

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Copyright © 2009 Cancer Research UK

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Effect of RAMP knockdown on apoptosis. (A) Double knockdown of RAMP/p53 and RAMP/p21 was performed in AGS cell. (A1) P53 and p21 knockdown was confirmed by western blot. (A2) Effect of knockdown RAMP, double knockdown RAMP/p53 or double knockdown RAMP/p21 on apoptosis of AGS cells, as determined by annexin V staining followed by flow cytometry. Values are expressed as the mean±s.d. of three replicate experiments. ^*P<0.01 compared with control siRNA; #P<0.01 compared with siRAMP. (B) Western blotting of cleaved caspase-8, caspase-9 and caspase-3 and cleaved PARP in AGS cells transfected with RAMP siRNA. (C) Protein expression of p53 and p21 in AGS and MKN45 cells on reduced RAMP expression. (D) Representative images of immunocytochemical staining of p53 in AGS cells after RAMP siRNA transfection.