Table 5.
Selected results from association analysis of 38 BANK1 SNPs in disease phenotype subsets based on ACR Clinical Criteria
| No subsetting (1892/2652) | Hematological Disorders | Immunological Disorders | Renal Involvement | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | |
| rs4699258 | 3.09E-04 | 0.85 (0.77–0.93) | 6.88E-02 | 0.88 (0.77–1.01) | 5.04E-05 | 0.78 (0.69–0.88) | 8.15E-02 | 0.87 (0.74–1.02) | |
| rs4572885 | 1.01E-02 | 0.89 (0.82–0.97) | 4.40E-01 | 0.95 (0.83–1.08) | 2.30E-03 | 0.84 (0.75–0.94) | 3.66E-01 | 0.93 (0.8–1.08) | |
| rs17266594 | 2.32E-05 | 0.82 (0.75–0.9) | 1.03E-01 | 0.89 (0.78–1.02) | 6.53E-06 | 0.76 (0.67–0.85) | 6.18E-03 | 0.8 (0.68–0.94) | |
| rs10516487 | 2.95E-05 | 0.82 (0.75–0.9) | 1.03E-01 | 0.89 (0.78–1.02) | 6.53E-06 | 0.76 (0.67–0.85) | 6.18E-03 | 0.8 (0.68–0.94) | |
| rs10516486 | 3.84E-04 | 0.86 (0.78–0.93) | 1.71E-01 | 0.91 (0.8–1.04) | 1.91E-04 | 0.8 (0.72–0.9) | 3.13E-02 | 0.85 (0.73–0.99) | |
| rs3733197 | 5.69E-03 | 0.88 (0.81–0.96) | 1.60E-01 | 0.91 (0.8–1.04) | 3.68E-03 | 0.84 (0.75–0.95) | 8.19E-01 | 0.98 (0.85–1.14) | |
| rs13125328 | 2.31E-01 | 0.92 (0.8–1.05) | 2.69E-01 | 0.89 (0.72–1.1) | 8.90E-03 | 0.78 (0.64–0.94) | 4.15E-01 | 0.91 (0.71–1.15) | |
| rs2850377 | 5.11E-02 | 0.92 (0.85–1) | 3.41E-01 | 0.94 (0.83–1.07) | 3.68E-02 | 0.89 (0.79–0.99) | 7.77E-01 | 0.98 (0.85–1.13) | |
| rs2631268 | 7.38E-02 | 1.09 (0.99–1.2) | 7.35E-02 | 1.14 (0.99–1.31) | 3.15E-02 | 1.14 (1.01–1.29) | 1.83E-02 | 1.21 (1.03–1.42) | |
| rs7685012 | 7.69E-01 | 1.02 (0.89–1.16) | 9.73E-01 | 1 (0.82–1.23) | 7.55E-01 | 1.03 (0.86–1.22) | 4.32E-02 | 1.25 (1.01–1.55) | |
| rs3113676 | 2.09E-01 | 0.79 (0.54–1.14) | 9.33E-01 | 0.98 (0.58–1.66) | 6.18E-01 | 0.89 (0.55–1.43) | 1.83E-02 | 0.32 (0.12–0.87) | |
| rs3113677 | 4.80E-02 | 0.83 (0.69–1) | 3.60E-02 | 0.73 (0.54–0.98) | 1.42E-01 | 0.83 (0.65–1.06) | 2.18E-03 | 0.55 (0.37–0.81) | |
| rs12649238 | 1.16E-01 | 1.09 (0.98–1.21) | 1.15E-01 | 1.14 (0.97–1.33) | 4.63E-02 | 1.15 (1–1.32) | 1.53E-01 | 1.14 (0.95–1.37) | |
| rs173218 | 8.20E-02 | 1.1 (0.99–1.22) | 7.73E-02 | 1.15 (0.98–1.35) | 4.89E-02 | 1.15 (1–1.32) | 1.32E-01 | 1.15 (0.96–1.38) | |
Abbreviation: OR, Odds Ratio; 95% CI, 95% Confidence Interval.
The numbers in parenthesis in the headings represent the (# cases meeting the tested criteria/total # controls). The p-values and odds ratios improvements are shown in bold.