Table 1.

Bone Marrow Transplantion Data for Feline MPS I

Recipient			Donor			Transplant Dose Bone Marrow Cells/kg			Days to engraft ment	Karyotype (% donor cells)				Time post engraft -ment at euth. or death	Transplant Results and Comments
Animal Number	Sex	Age (m)*	Coefficient of relatedness	Sex	Age (m)*	Dose 1	Dose 2	Dose 3		Months post- engraftment %		Months post- engraftment %
3680	M	2.7	0.57	F	2.7	7.3 × 108	6.7 × 107	1.1 × 109	41–47	0.1	≥ 91	12.3	≤ 7	13.4 m	Graft lost by-12 m post engraftment
4289	M	1.3	0.80	M	1.3	6.3 × 107	4.1 × 108	6.3 × 108	22–28					1 d**	Died 1 d post- engraftment/sub- capsular renal hemorhage
4296	M	5.4	0.77	M	5.4	4.0 × 108	7.4 × 107		10–14					35.8 m	Stable engraftment
4297	F	0.8	0.77	M	0.8	1.2 × 108	5.1× 108		11					2.2 m	Stable engraftment. Died 2.2 m post- engraftment/pylo- nephritis
4306	F	0.7	0.81	M	84.7	Buffy Coat	2 ml Bone Marrow		4–10					2 d	Died 1 d post- engraftment/hydronephrosis
4347	F	0.8	0.77	M	87.2	3.0 × 108	1.0× 108		10–13	3.5	≥ 95	32.7	≥ 95	36.8 m	Stable engraftment.
4349	M	0.8	0.80	F	0.8	1.3 × 108	NA†								Died post 2nd transplant/poss FIP‡
4366	F	1.1	0.77	M	4.7	NA	2.9× 108		6–10	3.2	≥ 95	32.4	≥ 95	36.3 m	Stable engraftment. History of seizure
4372	M	4.3	0.80	F	4.3	3.6 × 108	NA		9					17.7 m	Stable engraftment. IDDM 11 m post engraftment
4429	F	0.6	0.70	M	11.3	1.1 × 109	4.7× 108		NA					9 d	Died 9 days post engraftment/possibl e cardiomegaly
4583	F	3.3	0.89	M	3.3	1.1 × 109	4.5× 108		10–17			13.1	≥ 95	17.2 m	Stable engraftment

^*m = months,

^**d = days,

^†NA = not available,

^‡FIP = feline infectious peritonitis