Table A4.
Validation for 47 Probe Sets (1)
| U133 ID | High → | U95 ID | Validation With POG Data
|
Validation With COALL
|
Validation With DCOG
|
Symbol | Gene Description | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Odds Ratio of CCR | High → | P | P Adjusting for Subtype | Hazard Ratio | High → | P | P Adjusting for Subtype | Hazard Ratio | High → | P | P Adjusting for Subtype | |||||
| 35666_at | CCR | 0.8270 | CCR | .1652 | .2244 | 0.5347 | CCR | .0083 | .0150 | SEMA3F | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | |||||
| 227877_at | Fail | No match | 3.4569 | Fail | .0003 | .0079 | Similar to annexin II receptor (LOC389289), mRNA | |||||||||
| 227131_at | CCR | No match | 0.3778 | CCR | .0073 | .1170 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | ||||||||
| 205401_at | Fail | 39225_at | 0.7709 | Fail | .0308 | .0444 | 1.4191 | Fail | .0227 | .2417 | 1.7024 | Fail | .0114 | .0302 | AGPS | Alkylglycerone phosphate synthase |
| 208687_x_at | Fail | 1179_at | 0.8418 | Fail | .1050 | .3281 | 1.5373 | Fail | .0246 | .2826 | 1.7072 | Fail | .1138 | .1809 | HSPA8 | Heat shock 70 kDa protein 8 |
| 212229_s_at | CCR | No match | 0.1971 | CCR | .0005 | .0023 | FBXO21 | F-box only protein 21 | ||||||||
| 212576_at | CCR | 32235_at | 1.4168 | CCR | .0073 | .0526 | 0.5066 | CCR | .0355 | .0157 | 0.1713 | CCR | .0061 | .1709 | MGRN1 | Mahogunin, ring finger 1 |
| 225446_at | CCR | No match | 0.7464 | CCR | .2590 | .3139 | C21orf107 | Chromosome 21 open reading frame 107 | ||||||||
| 224793_s_at | CCR | No match | 0.5579 | CCR | .0332 | .0333 | TGFBR1 | Transforming growth factor, β receptor I (activin A receptor type II-like kinase, 53 kDa) | ||||||||
| 221840_at | CCR | No match | 0.5599 | CCR | .0001 | .1409 | 0.4861 | CCR | .0073 | .0796 | PTPRE | Protein tyrosine phosphatase, receptor type, E | ||||
| 203514_at | CCR | No match | 0.2618 | CCR | < .0001 | .0103 | 0.5114 | CCR | .0498 | .4390 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | ||||
| 1559018_at | CCR | No match | 0.7534 | CCR | .1851 | .2120 | PTPRE | Protein tyrosine phosphatase, receptor type, E | ||||||||
| 217499_x_at | Fail | No match | 1.6161 | Fail | .0358 | .3588 | 2.9133 | Fail | .0661 | .4768 | OR7E47P | Olfactory receptor, family 7, subfamily E, member 47 pseudogene | ||||
| 224187_x_at | Fail | 1180_g_at | 0.7093 | Fail | .0078 | .0846 | 2.0577 | Fail | .0639 | .0990 | HSPA8 | Heat shock 70 kDa protein 8 | ||||
| 40637_at | 0.8986 | Fail | .2164 | .5032 | ||||||||||||
| 221891_x_at | Fail | 33820_g_at | 0.8539 | Fail | .1247 | .4082 | 1.6161 | Fail | .0399 | .0533 | 1.6902 | Fail | .1898 | .2258 | HSPA8 | Heat shock 70 kDa protein 8 |
| 201642_at | CCR | 41140_at | 0.8839 | Fail | .8166 | .8323 | 0.8781 | CCR | .2963 | .4960 | 1.0325 | Fail | .5284 | .6506 | IFNGR2 | Interferon γ receptor 2 (interferon γ transducer 1 |
| 218418_s_at | CCR | No match | 0.6570 | CCR | .0065 | .1875 | 0.4928 | CCR | .0008 | .0135 | ANKRD25 | Ankyrin repeat domain 25 | ||||
| 242305_at | Fail | No match | 4.5128 | Fail | .0103 | .0057 | CDNA FLJ42757 fis, clone BRAWH3001712 | |||||||||
| 216035_x_at | CCR | No match | 0.5543 | CCR | .0000 | .0222 | 0.5389 | CCR | .0099 | .0514 | TCF7L2 | Transcription factor 7-like 2 (T-cell specific, HMG-box) | ||||
| 1556321_a_at | CCR | No match | 0.2974 | CCR | .0037 | .0127 | mRNA full-length insert cDNA clone EUROIMAGE 283668 | |||||||||
| 235014_at | Fail | No match | 2.6793 | Fail | .0476 | .0921 | LOC147727 | Hypothetical protein LOC147727 | ||||||||
| 208820_at | CCR | 36117_at | 1.1822 | CCR | .1137 | .2828 | 0.8187 | CCR | .0481 | .1307 | 0.6916 | CCR | .0725 | .4788 | PTK2 | PTK2 protein tyrosine kinase 2 |
| 212231_at | CCR | 32169_at | 1.3503 | CCR | .0194 | .1161 | 0.6376 | CCR | .0545 | .3078 | 0.3293 | CCR | .0068 | .0121 | FBXO21 | F-box only protein 21 |
| 229618_at | CCR | No match | 0.8772 | CCR | .3791 | .2522 | SNX16 | Sorting nexin 16 | ||||||||
| 209033_s_at | CCR | 1512_at | 1.0524 | CCR | .3541 | .2722 | 0.7866 | CCR | .2308 | .4579 | 0.3686 | CCR | .0303 | .0066 | DYRK1A | Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| 36946_at | 1.0186 | CCR | .4464 | .4112 | ||||||||||||
| 200641_s_at | CCR | 34642_at | 1.0255 | CCR | .4269 | .3071 | 0.9139 | CCR | .3670 | .3979 | 1.1687 | Fail | .6451 | .6822 | YWHAZ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide |
| 202657_s_at | Fail | 37312_at | 1.0611 | CCR | .6674 | .6212 | 1.3910 | Fail | .1106 | .2672 | 3.4313 | Fail | .0050 | .1299 | SERTAD2 | SERTA domain containing 2 |
| 201099_at | CCR | No match | 0.9324 | CCR | .3890 | .3773 | 0.3949 | CCR | .0241 | .0022 | USP9X | Ubiquitin-specific protease 9, X-linked (fat facets-like, Drosophila) | ||||
| 201542_at | CCR | No match | 0.4317 | CCR | .0086 | .1713 | 0.2702 | CCR | .0050 | .0048 | SARA1 | SAR1a gene homolog 1 (S. cerevisiae) | ||||
| 227068_at | CCR | No match | 0.5209 | CCR | .0565 | .0508 | PGK1 | Phosphoglycerate kinase 1 | ||||||||
| 213944_x_at | CCR | 41476_at | 0.8669 | Fail | .8518 | .7282 | 0.9231 | CCR | .4079 | .3152 | 0.4148 | CCR | .0360 | .4760 | GNA11 | Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
| 201472_at | CCR | 171_at | 1.1376 | CCR | .1773 | .1634 | 0.7118 | CCR | .0734 | .4987 | 0.6076 | CCR | .1698 | .1764 | VBP1 | von Hippel-Lindau binding protein |
| 202806_at | CCR | 37981_at | 1.8523 | CCR | .0001 | .0007 | 0.7634 | CCR | .0785 | .3280 | 0.4670 | CCR | .0244 | .2112 | DBN1 | drebrin 1 |
| 221918_at | CCR | No match | 0.5827 | CCR | .0124 | .1428 | 0.4768 | CCR | .0492 | .0195 | PCTK2 | PCTAIRE protein kinase 2 | ||||
| 214585_s_at | Fail | 32658_at | 0.9215 | Fail | .2743 | .2793 | 1.3231 | Fail | .0597 | .0929 | 4.3420 | Fail | .0448 | .0391 | VPS52 | Vacuolar protein sorting 52 (yeast) |
| 219078_at | Fail | No match | 1.0618 | Fail | .3451 | .3739 | 2.9254 | Fail | .0090 | .2201 | GPATC2 | G patch domain containing 2 | ||||
| 219133_at | Fail | No match | 2.3405 | Fail | .0612 | .0998 | FLJ20604 | Hypothetical protein FLJ20604 | ||||||||
| 1558111_at | Fail | No match | 2.0333 | Fail | .0287 | .1407 | MBNL1 | Muscleblind-like (Drosophila) | ||||||||
| 221773_at | CCR | No match | 0.7483 | CCR | .0001 | .4428 | 0.5803 | CCR | .0046 | .3046 | ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | ||||
| 1558732_at | CCR | No match | 0.3631 | CCR | .0015 | .0369 | gb:AK074900.1/DB_XREF = gi:22760646/TID = Hs2.382077.1/CNT = 11/FEA = mRNA/... | |||||||||
| 212441_at | CCR | 37748_at | 1.4004 | CCR | .0118 | .0312 | 0.5488 | CCR | .0010 | .1296 | 0.3673 | CCR | .0171 | .0250 | KIAA0232 | KIAA0232 gene product |
| 226775_at | CCR | No match | 0.3359 | CCR | .0221 | .0963 | e(y)2 | e(y)2 protein | ||||||||
| 208498_s_at | Fail | 36680_at | 0.9858 | Fail | .4582 | .7287 | 1.0305 | Fail | .4201 | .0957 | 1.6438 | Fail | .0508 | .3211 | AMY2B | Amylase, α 2B; pancreatic |
| 201121_s_at | CCR | 38802_at | 1.1054 | CCR | .2349 | .1222 | 0.3499 | CCR | .0007 | .0377 | 0.3753 | CCR | .0256 | .0257 | PGRMC1 | Progesterone receptor membrane component 1 |
| 202984_s_at | CCR | No match | 0.8270 | CCR | .1357 | .3122 | 0.3916 | CCR | .0152 | .0197 | BAG5 | BCL2-associated athanogene 5 | ||||
| 210338_s_at | Fail | No match | 1.4333 | Fail | .0590 | .1634 | 1.6945 | Fail | .1165 | .1925 | HSPA8 | Heat shock 70 kDa protein 8 | ||||
| 206548_at | CCR | No match | 0.7866 | CCR | .0156 | .3473 | 0.4007 | CCR | .0003 | .0025 | FLJ23556 | Hypothetical protein FLJ23556 | ||||
NOTE. P values are one sided and uncorrected for multiple testing.
Abbreviations: ID, identification; POG, Pediatric Oncology Group; COALL, German Cooperative Study Group for Childhood ALL; ALL, acute lymphoblastic leukemia; DCOG, Dutch Childhood Oncology Group; CCR, complete continuous remission; Fail, relapse.