Table 5.
Validation of the Outcome Signature on COALL Data Set
| Model | Analyses
|
|||||
|---|---|---|---|---|---|---|
| Univariate
|
Multivariate Adjusted for Age and WBC
|
Multivariate Adjusted for ALL Subtype*
|
||||
| Hazard Ratio | P | Hazard Ratio | P | Hazard Ratio | P | |
| I (LP1) | 0.898 | .015 | 0.917 | .041 | 0.934 | .135 |
| II (LP2) | 0.993 | .009 | 0.994 | .017 | 0.997 | .17 |
| III (LP3) | 0.961 | .020 | 0.967 | .036 | 0.983 | .23 |
NOTE. Total number of patients in data set = 145. Data were analyzed with the U133A microarray.
Abbreviations: COALL, German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia; ALL, acute lymphoblastic leukemia; MLL, mixed lineage leukemia; BCR, break point cluster region; ABL, Abelson murine leukemia viral oncogene; TEL, translocation ETS leukemia, AML, acute myeloid leukemia.
*
Analysis was adjusted for MLL, BCRABL, TEL/AML1, hyperdiploid, and E2A subtypes.