Table 6.
Validation of the Outcome Signature on DCOG Data Set
| Model | Analyses
|
|||||
|---|---|---|---|---|---|---|
| Univariate
|
Multivariate Adjusted for Age and WBC
|
Multivariate Adjusted for ALL Subtype*
|
||||
| Hazard Ratio | P | Hazard Ratio | P | Hazard Ratio | P | |
| I (LP1) | 0.836 | .010 | 0.919 | .155 | 0.981 | .415 |
| II (LP2) | 0.987 | .016 | 0.991 | .090 | 0.991 | .100 |
| III (LP3) | 0.938 | .047 | 0.968 | .215 | 0.981 | .350 |
NOTE. Total number of patients in data set = 92. Data were analyzed with the U133Plus2.0 microarray.
Abbreviations: COALL, German Cooperative Study Group for childhood acute lymphoblastic leukemia; ALL, acute lymphoblastic leukemia; MLL, mixed lineage leukemia; BCR, break point cluster region; ABL, Abelson murine leukemia viral oncogene; TEL, translocation ETS leukemia; AML, acute myeloid leukemia.
*
Analysis was adjusted for MLL, BCRABL, TEL/AML1, hyperdiploid, and E2A subtypes.