Table 3.

BuChE inhibition in relation to PON1 Q192R genotype and level of plasma PON1 activity.

		Unadjusteda		Adjustedb
PON1 status	No.	β-Coefficient	p-Value	β-Coefficient	p-Value
Q192R genotype	110		0.062c		0.028c
RR	33	Reference	—	Reference	—
QR	55	−1.82	0.445	−3.36	0.130
QQ	22	−5.72	0.056	−6.58	0.030
Level of plasma PON1 activityd	110	0.061	0.048	0.061	0.053

^aQ192R genotype and level of plasma PON1 activity analyzed in separate models using linear regression with robust standard error estimates. This analysis was restricted to 110 records with nonmissing data for all covariates that were included in the adjusted model.

^bQ192R genotype and level plasma PON1 activity in same model, and adjusted for year of participation, days since baseline ChE test, age in years, and cumulative exposure score. Multiple linear regression with robust standard error estimates was used.

^cTest for trend by number of Q alleles.

^dBased on AREase activity (U/mL). The coefficient represents the difference in BuChE inhibition for a one-unit increase in AREase activity.