Table 2.
Unadjusted Alu and LINE-1 methylation of cord blood (%) by quartiles of lead exposures.
| Variable | No. | Alu ± SD | LINE-1 ± SD |
|---|---|---|---|
| Overall mean | 103 | 25.76 ± 1.04 | 79.48 ± 2.18 |
|
Maternal tibia lead (μg/g) | |||
| ≤ 4.8 | 25 | 26.00 ± 0.94 | 79.72 ± 2.16 |
| > 4.8 and ≤ 9.7 | 26 | 25.78 ± 0.84 | 79.31 ± 2.53 |
| > 9.7 and ≤ 16.4 | 26 | 25.75 ± 1.07 | 79.55 ± 2.01 |
| > 16.4 | 25 | 25.71 ± 1.07 | 79.37 ± 2.11 |
| p-Value for trenda | 0.04 | 0.38 | |
|
Maternal patella lead (μg/g) | |||
| ≤ 2.2 | 25 | 25.65 ± 0.75 | 80.08 ± 2.33 |
| > 2.2 and ≤ 12.1 | 25 | 26.18 ± 1.06 | 79.78 ± 1.68 |
| > 12.1 and ≤ 21.8 | 25 | 25.84 ± 0.99 | 79.25 ± 1.91 |
| > 21.8 | 25 | 25.52 ± 1.02 | 78.57 ± 2.48 |
| p-Value for trenda | 0.10 | 0.007 | |
|
Cord blood lead (μg/dL) | |||
| ≤ 4.4 | 25 | 25.68 ± 1.00 | 79.17 ± 2.09 |
| > 4.4 and ≤ 6.2 | 27 | 25.73 ± 1.13 | 79.37 ± 1.99 |
| > 6.2 and ≤ 7.9 | 26 | 25.99 ± 0.77 | 79.84 ± 2.13 |
| > 7.9 | 25 | 25.79 ± 1.00 | 79.55 ± 2.55 |
| p-Value for trenda | 0.33 | 0.46 | |
a
Obtained using mixed-effects models.