Table 3.
Adjusted ORs (95% CIs) for cryptorchidism and hypospadias in relation to maternal PCB levels (mmol/L), CPP, 1959–1965.
| Percentiles among controls
|
Cryptorchidism
|
Hypospadias
|
||||
|---|---|---|---|---|---|---|
| 25th | 50th | 75th | 95th | Adjusteda OR (95% CI) | Adjusteda OR (95% CI) | |
| PCB congener | ||||||
| PCB-28 | 0.39 | 0.70 | 0.97 | 1.79 | 1.07 (0.86–1.34) | 1.07 (0.86–1.32) |
| PCB-52 | 0.00 | 0.00 | 0.00 | 0.51 | 1.11 (0.81–1.52) | 0.80 (0.42–1.52) |
| PCB-74 | 0.51 | 0.79 | 1.13 | 2.16 | 1.04 (0.87–1.25) | 1.03 (0.84–1.26) |
| PCB-105 | 0.00 | 0.34 | 0.52 | 1.19 | 1.11 (0.82–1.50) | 1.03 (0.69–1.53) |
| PCB-118 | 1.13 | 1.65 | 2.39 | 5.21 | 1.03 (0.95–1.12) | 0.99 (0.88–1.11) |
| PCB-138 | 1.16 | 1.61 | 2.36 | 3.85 | 1.09 (0.94–1.25) | 1.08 (0.93–1.26) |
| PCB-153 | 1.22 | 1.69 | 2.52 | 4.02 | 1.11 (0.97–1.27) | 1.12 (0.98–1.30) |
| PCB-170 | 0.00 | 0.23 | 0.38 | 0.66 | 1.07 (0.59–1.94) | 1.34 (0.73–2.46) |
| PCB-180 | 0.35 | 0.56 | 0.83 | 1.39 | 1.19 (0.84–1.69) | 1.28 (0.89–1.84) |
| PCB-194 | 0.00 | 0.00 | 0.21 | 0.37 | 1.42 (0.54–3.72) | 1.41 (0.48–4.19) |
| PCB-203 | 0.00 | 0.00 | 0.21 | 0.42 | 1.79 (0.71–4.52) | 1.99 (0.75–5.28) |
| Sum of PCBs | 5.29 | 7.86 | 10.92 | 19.48 | 1.01 (0.99–1.04) | 1.01 (0.98–1.04) |
| UPD-GT inducers | 1.44 | 2.15 | 3.12 | 6.19 | 1.03 (0.96–1.11) | 1.01 (0.92–1.11) |
| Wolff groups | ||||||
| 1A | 0.00 | 0.00 | 0.00 | 0.51 | 1.11 (0.81–1.52) | 0.80 (0.42–1.52) |
| 2A | 1.78 | 2.61 | 3.75 | 8.06 | 1.02 (0.97–1.07) | 1.00 (0.94–1.07) |
| 2B | 1.22 | 1.75 | 2.66 | 4.41 | 1.07 (0.94–1.21) | 1.07 (0.94–1.22) |
| 3 | 1.59 | 2.30 | 3.49 | 5.59 | 1.08 (0.98–1.18) | 1.09 (0.98–1.20) |
| TEF Groups | ||||||
| Mono-ortho | 1.19 | 1.93 | 2.85 | 6.13 | 1.02 (0.96–1.10) | 0.99 (0.91–1.09) |
| Di-ortho | 0.38 | 0.73 | 1.21 | 1.97 | 1.09 (0.87–1.38) | 1.16 (0.92–1.48) |
| Molecular weight groups | ||||||
| Low | 2.31 | 3.36 | 4.68 | 9.98 | 1.02 (0.97–1.06) | 1.00 (0.95–1.06) |
| High | 2.8 | 4.21 | 6.32 | 10.27 | 1.04 (0.98–1.09) | 1.04 (0.98–1.10) |
a
Results are from conditional logistic regression, conditioned on study center and adjusted for serum DDE level (5 strata), triglycerides, and cholesterol. OR is change in lnOR per mmol/L increase in PCB.