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. 2009 Jul 28;2(9-10):467–478. doi: 10.1242/dmm.001438

Fig. 2.

Fig. 2.

Hex and Islet-1 (Isl1) gene expression patterns after 8 and 24 hours in control embryos and in Li- or HCy-exposed embryos. (A,B,G,H) In control embryos (Con, top row), both Hex and Isl1 expression are seen at relatively high levels after an 8-hour (A,G) and 24-hour (B,H) incubation. The black arrows indicate in situ gene expression. Hex and Isl1 gene expression are suppressed in chick embryos following Li (C, second row) or HCy (E, bottom row) exposure at HH stages 3+/4–. A recovery in gene expression is noted by 24 hours (D,F), but embryos remain delayed in their development. Modulation of Isl1 is similar: little or no Isl1 gene expression is detectable following 8 hours of exposure to Li (I) or HCy (K). By 24 hours, heart development is delayed and cardiac anomalies arise (J,L). In all panels, the embryonic anterior is at the top. Bars, 300 μm.