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Inhibition Effects on sLO-1 Substrate Specificity for AA vs. LA
| Inhibitor (Type) | OA (Competitive) | PS (Mixed-Type) | OS (Allosteric) | ||||
|---|---|---|---|---|---|---|---|
| [Inhibitor] | 0 μM | 11 μM | 55 μM | 13 μM | 65 μM | 1 μM | 5 μM |
| (kcat/KM)AA/(kcat/KM)LA | 1.8 ± 0.2 | 2.0 ± 0.2 | 1.9 ± 0.1 | 2.3 ± 0.2 | 4.0 ± 0.3 | 3.2 ± 0.4 | 4.8 ± 0.3 |
aEnzymatic assays were at performed at 1 μM total substrate concentrations in 100 mM Borate (pH 9.2) at 22 °C.
