Table I.
Characteristics of Study Population.
| Characteristic | All (N=17) | Low FPIR (N=4) | Normal FPIR (N=10) | High FPIR (N=3) | p-value |
|---|---|---|---|---|---|
| Age at IVGTT | 10.8 ± 3.6 | 8.7 ± 2.8 | 11.2 ± 4.2 | 12.1 ± 0.7 | ns |
| Female sex - N (%) | 5 (30) | 1 (25) | 3 (30) | 1 (33) | ns |
| Low BMI (Z-score < -2)–N (%) | 4 (24) | 3 (75) | 0 | 1 (33) | 0.01 |
| Pubertal - N (%) | 8 (47) | 1 (25) | 5 (50) | 2 (67) | ns |
| Steroid treatment at time of IVGTT - N (%) | 4 (24) | 0 | 3 (30) | 1 (33) | ns |
| GH treatment at time of IVGTT - N (%) | 1 (6) | 0 | 1 (10) | 0 | ns |
| Complementation Group† | |||||
| A - N (%) | 11 (65) | 2 (100) | 7 (78) | 2 (67) | ns |
| B - N (%) | 1 (6) | 0 | 1 (10) | 0 | ns |
| D1 - N (%) | 1 (6) | 0 | 1 (10) | 0 | ns |
| G - N (%) | 1 (6) | 0 | 0 | 1 (33) | ns |
| Age at HCT | 9.2 ± 3.7 | 7.6 ± 1.7 | 9.6 ± 4.6 | 9.8 ± 2.5 | ns |
| Time since HCT | 1.6 ± 1.3 | 1.1 ± 1.4 | 1.6 ± 1.2 | 2.3 ±1.8 | ns |
| Donor/source HCT | |||||
| Related marrow | 4 (24) | 1 (25) | 3 (30) | 0 | ns |
| Unrelated marrow - N (%) | 9 (53) | 3 (75) | 4 (40) | 2 (67) | ns |
| Cord - N (%) | 4 (23) | 0 | 3 (30) | 1 (33) | ns |
| aGVHD - N (%) | 3 (18) | 0 | 2 (20) | 1 (33) | ns |
| cGVHD - N (%) | 2 (12) | 0 | 2 (20) | 0 | ns |
| Total body irradiation – N (%) | 12 (71) | 3 (75) | 6 (60) | 3 (100) | ns |
| Fasting insulin – median (Q1, Q3) | 6.5 (4, 9.5) | 3.8 (2.3, 4.8) | 7 (4.5, 8.0) | 21 (10, 22.5) | 0.0002 |
| HOMA-IR – median (Q1, Q3) | 1.5 (0.9, 2.0) | 0.8 (0.5, 1.0) | 1.6 (0.9, 1.9) | 4.7 (2.1, 5.1) | 0.0095 |
| Glucose AUC – median (Q1, Q3)** | 1230 (975,1665) | 1125 (825, 1425) | 1305 (975, 1665) | 1230 (1095, 1920) | ns |
| HOMA β-cell function – median (Q1, Q3) | 91 (57, 130) | 57 (45, 86) | 82 (65, 122) | 265 (152, 279) | 0.0231 |
| Insulin AUC – median (Q1, Q3)** | 1245 (1215, 1800) | 728 (210, 1245) | 1335 (1215, 1335) | 1605 (1230, 8355) | ns |
| Lipids | |||||
| Triglycerides† | 106 ± 64 | 69 ± 32 | 102 ± 70 | 153 ± 56 | ns |
| Cholesterol† | 172 ± 35 | 153 ± 23 | 172 ± 41 | 192 ± 24 | ns |
| Low density lipoprotein (LDL)* | 95 ± 23 | 89 ± 10 | 86 ± 23 | 120 ± 16 | ns |
| High density lipoprotein (HDL)* | 51 ± 17 | 50 ± 19 | 58 ± 16 | 41 ±17 | ns |
| Percent body fat† | 22 ± 7.3 | 17 ± 4a | 21 ± 6a | 32 ± 2b | 0.0079 |
| Elevated systolic blood pressure – N (%) | 5 (29) | 0 | 3 (30) | 2 (67) | ns |
Plus-minus values are means ± SD. Median, first and third quartiles (Q1 and Q3), are presented for skewed variables. P-value for differences between the low, normal, and high groups. FPIR=first phase insulin release; IVGTT=intravenous glucose tolerance test; HCT=hematopoietic cell transplantation; BMI=body mass index; aGVHD=acute graft versus host disease; cGVHD=chronic graft versus host disease; GH=growth hormone; AUC=area under the curve; ns=no significant difference.
†
Data available for 13 participants;
*
Data available for 12 participants;
**
Data available for 11 participants.