Fig. 2.

Characterization of TBA2 transgenic mice. Picture of a wildtype (WT) and a TBA2 mouse showing that TBA2 mice are generally smaller (a) and that they display a crooked posture (b). c Both female and male TBA2 mice showed a reduced body weight compared with their age-matched WT littermates. d Macroscopic analysis of TBA2 brains revealed an atrophic cerebellum when compared with age-matched WT littermates. e TBA2 mice displayed a significantly reduced survival rate compared with WT littermates (P = 0.0002; Logrank test)