Table 1.

Age, sex and neuropathology of human cases studied

No.	Age	Sex	Neurofibrillary changesa	Amyloida	Classification
1	22	M	0	0	Non-pathological controls
2	49	F	0	0
3	70	F	0	0
4	77	M	0	0
5	21	F	I	0	Minimal tau pathology
6b	49	F	I	0
7	71	F	I	0
8	88	F	I	0
9	92	M	II	0	Maximal tau pathology without concurrent amyloid
10	60	M	V	C	Alzheimer’s disease
11	77	F	V	C
12	87	M	V	B
13	85	F	VI	C
14	52	F	VI	C	Down’s syndrome
15	59	M	VI	C
16	43	M	0	B	High amyloid burden without concurrent tau pathology
17	44	F	0	B
18	56	M	0	A
19	63	M	0	B

^aStaging of neuropathology according to Braak and Braak [4]; amyloid stages: A, low density of deposits in isocortex with no involvement of hippocampus; B, medium density of deposits in isocortex with mild involvement of hippocampus; C, high density of deposits in isocortex with mild involvement of hippocampus. All cases were stage 0 synucleinopathies

^bSubject died with sepsis