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. Author manuscript; available in PMC: 2009 Sep 3.

Published in final edited form as: J Clin Endocrinol Metab. 2008 Sep 9;93(12):4697–4706. doi: 10.1210/jc.2008-1101

Median-Joining (MJ) networks of predicted haplotypes in the 5′ upstream region of CGB5 (A) and CGB8 (B). Singleton polymorphisms were excluded from the analysis, because of unreliable phasing. The size of each node is proportional to the haplotype frequency in the total dataset. The relative distribution of each haplotype among the recurrent miscarriage (RM) cases (black) and fertile controls (white) is indicated. Haplotype nomenclature is shown in Supplementary Table S2. (A) The carrier status of haplotypes H1-H2 and H10-H11 lowered 1.7-fold the risk of RM. (B) Haplotype H2 defined by the minor allele of a proximal promoter mutation c8EF-4 was exclusively identified in RM patients in both study populations, Estonians and Finns.

MJ networks of predicted haplotypes in the genic regions of CGB5 and CGB8 are shown in Supplementary Fig. S3.

Median-Joining (MJ) networks of predicted haplotypes in the 5′ upstream region of CGB5 (A) and CGB8 (B). Singleton polymorphisms were excluded from the analysis, because of unreliable phasing. The size of each node is proportional to the haplotype frequency in the total dataset. The relative distribution of each haplotype among the recurrent miscarriage (RM) cases (black) and fertile controls (white) is indicated. Haplotype nomenclature is shown in Supplementary Table S2. (A) The carrier status of haplotypes H1-H2 and H10-H11 lowered 1.7-fold the risk of RM. (B) Haplotype H2 defined by the minor allele of a proximal promoter mutation c8EF-4 was exclusively identified in RM patients in both study populations, Estonians and Finns.

MJ networks of predicted haplotypes in the genic regions of CGB5 and CGB8 are shown in Supplementary Fig. S3.