. Author manuscript; available in PMC: 2009 Sep 3.

Published in final edited form as: J Clin Endocrinol Metab. 2008 Sep 9;93(12):4697–4706. doi: 10.1210/jc.2008-1101

TABLE 2.

Diversity parameters and neutrality tests of the CGB5 and CGB8 genes in fertile women and patients of recurrent miscarriages (RM)

	CGB5			CGB8
	Full region^a	5′upstream region^b	Genic region^c	Full region^a	5′upstream region^b	Genic region^c
No of SNPs	46	17	29	23	3	20
Fertile women
Diversity (π)^d	0.00193	0.00271	0.00169	0.00119	0.00201	0.00095
Tajima D^e	-1.12980	-1.16944	-0.88132	-0.35277	2.29389 ^*	-0.96141
P-value of Ewens-Watterson F statistic^f	ns	ns	ns	ns	0.007	ns
RM Patients
Diversity (π)^d	0.00172	0.00195	0.0016	0.00115	0.00199	0.0009
Tajima D^e	-1.23744	-1.23550	-0.91052	-0.56306	1.26879	-1.06361
P-value of Ewens-Watterson F statistic^f	ns	ns	ns	ns	ns	ns

SNPs in 5′upstream and genic regions

SNPs located in the region of −435 bp up to −1 bp from the start site of mRNA sequence

SNPs located in mRNA seqence: +1 bp up to +1082 bp from the start site of mRNA sequence

Estimate of nucleotide diversity (π) per basepair from average pairwise differences among individuals

The basis of the Tajima’s D statistics (D^T) is the difference between observed (π) and expected (θ) diversity estimates: under neutral conditions π = θ and D^T = 0

This statistic tests the observed allele frequency spectrum with the expected allele frequency spectrum under the neutral model (Hardy-Weinberg Equilibrium).

p=0.0169; ns - non-significant (p>0.05)