TABLE 3.
Variants in CGB5 and CGB8 genes significantly associated with recurrent miscarriage (RM). Association P-values and odds ratio (OR) with 95% confidence interval (CI) was calculated by Cochran-Armitage test for trend
| Estonians (n=194) | Finns (n=185) | All individuals (n=379) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF (%) | p-value | OR (95%CI) |
MAF (%) | p-value | OR (95%CI) |
MAF (%) | p-value | OR (95%CI) |
||||
| SNP | Fertile women n=95 |
RM patients n=99 |
Fertile women n=100 |
RM patients n=85 |
Fertile women n=195 |
RM patients n=184 |
||||||
| c5EF-155 | 13.16 | 8.08 | 0.083 | 0.54 (0.27-1.1) |
11.50 | 6.55 | 0.129 | 0.58 (0.29-1.19) |
12.31 | 7.38 | 0.024 | 0.57 (0.35-0.93) |
| c5EF-147 | 13.16 | 8.08 | 0.083 | 0.54 (0.27-1.1) |
11.00 | 5.95 | 0.094 | 0.52 (0.24-1.13) |
12.05 | 7.10 | 0.018 | 0.54 (0.32-0.91) |
| c5EF-144 | 13.16 | 8.08 | 0.083 | 0.54 (0.27-1.1) |
13.00 | 7.74 | 0.131 | 0.61 0.31-1.17) |
13.08 | 7.92 | 0.023 | 0.58 (0.36-0.93) |
| c5EF-142 | 13.16 | 8.08 | 0.083 | 0.54 (0.27-1.1) |
13.00 | 7.74 | 0.131 | 0.61 (0.31-1.17) |
13.08 | 7.92 | 0.023 | 0.58 (0.36-0.93) |
| c5EF1038 | 14.47 | 9.09 | 0.079 | 0.57 (0.30-1.08) |
14.00 | 7.06 | 0.036 | 0.48 (0.24-0.97) |
14.36 | 8.15 | 0.007 | 0.53 (0.32-0.85) |
| c8EF301* | 5.79 | 5.05 | 0.740 | 0.86 (0.35-2.12) |
8.85 | 3.21 | 0.034 | 0.35 (0.12-0.96) |
7.33 | 4.24 | 0.072 | 0.55 (0.29-1.06) |
| c8EF1045* | 0.53 | 0.51 | 0.977 | 0.97 (0.06-15.6) |
3.13 | 0 | 0.025 | na | 1.83 | 0.28 | 0.042 | 0.15 (0.02-1.03) |
*
significant association (p<0.05) only in one population
MAF - minor allele frequency; na - not applicable as monomorphic among fertile women