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. Author manuscript; available in PMC: 2009 Sep 23.
Published in final edited form as: Chembiochem. 2009 Mar 23;10(5):911–919. doi: 10.1002/cbic.200800752

Figure 1.

Figure 1

Post-translational modifications in lantibiotic biosynthesis. A) Biosynthesis of lacticin 481. The bifunctional enzyme LctM is responsible for both dehydration of Ser/Thr residues and the subsequent intramolecular cyclization of Cys residues onto the unsaturated amino acids Dha and Dhb in the structural region (also called propeptide). Subsequent proteolytic removal of the unmodified leader peptide by LctT provides bioactive lacticin 481. B) Formation of Lan and MeLan. Dehydration is catalyzed via an intermediate phosphorylation step, which targets Ser/Thr residues for elimination.