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Western blot analysis of the biochemical response of MDAMB231 cells treated with MEK inhibitor CI1040, EGFR inhibitor gefitinib, or their combination in low (0.1% FBS) and full (10% FBS) serum conditions. Cells were harvested at 4 h after drug treatment. In low serum conditions and in the presence of EGF, MEK inhibition results in strong phosphorylated EGFR (p-EGFR) and p-AKT up-regulation, which is abrogated by EGFR inhibitor.
