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Predicting viral escape. The highly conserved tat/rev target is shown with flanking sequences. The 19 nucleotide target sequence encompasses two overlapping reading frames for tat and rev. For each reading frame the codons and amino acid sequence are shown. Numerous silent codon changes are possible in each reading frame (grey box), but a silent mutation in both reading frames is possible only at 2 positons within the target sequence (black box).
