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. 2005 Oct 11;1(2):66–78.

Figure 2.

Figure 2.

Prom-A siRNA inhibits syncytia formation and host cell death. (A) HIV-prom-A siRNA reduces syncytium formation in infected MAGIC-5 cells (Phase-contrast microscopy of MAGIC-5 cells at 200X magnification). The time points indicate days after infection (see Fig. 1B). The prominent syncytia seen in the mock-transfected cells are absent from the HIV-prom-A siRNA transfected culture. (B) Caspase-3 activity is reduced to normal levels in HIV-1 infected cells by transfection of HIV-prom-A siRNA. Caspase-3 activity (red) is detected in MAGIC-5 cells transfected with siRNA 7 days earlier. DAPI staining (blue) outlines the nuclei, and cell structure was highlighted by Vimentin staining (green). NC indicates non-infected MAGIC-5 cells.