Table 2.
Synthetic siRNAs used in this study. Sense- and antisense-stranded siRNA elements are indicated by ‘-ss’ and ‘-as’, respectively.
| siRNAs against the Swedish APP mutant | |
|---|---|
| Name | Sequence (5′---------------3′) |
| si(T7/C8)-ss | AGUGAAUCUGGAUGCAGAAUUU |
| si(T7/C8)-as | AUUCUGCAUCCAGAUUCACUUU |
| si(T8/C9)-ss | AAGUGAAUCUGGAUGCAGAAUU |
| si(T8/C9)-as | UUCUGCAUCCAGAUUCACUUUU |
| si(T9/C10)-ss | GAAGUGAAUCUGGAUGCAGAUU |
| si(T9/C10)-as | UCUGCAUCCAGAUUCACUUCUU |
| si(T10/C11)-ss | UGAAGUGAAUCUGGAUGCAGUU |
| si(T10/C11)-as | CUGCAUCCAGAUUCACUUCAUU |
| si(T11/C12)-ss | CUGAAGUGAAUCUGGAUGCAUU |
| si(T11/C12)-as | UGCAUCCAGAUUCACUUCAGUU |
| si(T12/C13)-ss | UCUGAAGUGAAUCUGGAUGCUU |
| si(T12/C13)-as | GCAUCCAGAUUCACUUCAGAUU |
| siRNAs against the London APP mutants | |
|---|---|
| Name | Sequence (5′---------------3′) |
| si(A8)-ss | AGUGAUCAUCAUCACCUUGUU |
| si(A8)-as | CAAGGUGAUGAUGAUCACUUU |
| si(A9)-ss | CAGUGAUCAUCAUCACCUUUU |
| si(A9)-as | AAGGUGAUGAUGAUCACUGUU |
| si(A10)-ss | ACAGUGAUCAUCAUCACCUUU |
| si(A10)-as | AGGUGAUGAUGAUCACUGUUU |
| si(A11)-ss | GACAGUGAUCAUCAUCACCUU |
| si(A11)-as | GGUGAUGAUGAUCACUGUCUU |
| si(A12)-ss | CGACAGUGAUCAUCAUCACUU |
| si(A12)-as | GUGAUGAUGAUCACUGUCGUU |
| si(T8)-ss | AGUGAUCUUCAUCACCUUGUU |
| si(T8)-as | CAAGGUGAUGAAGAUCACUUU |
| si(T9)-ss | CAGUGAUCUUCAUCACCUUUU |
| si(T9)-as | AAGGUGAUGAAGAUCACUGUU |
| si(T10)-ss | ACAGUGAUCUUCAUCACCUUU |
| si(T10)-as | AGGUGAUGAAGAUCACUGUUU |
| si(T11)-ss | GACAGUGAUCUUCAUCACCUU |
| si(T11)-as | GGUGAUGAAGAUCACUGUCUU |
| si(T12)-ss | CGACAGUGAUCUUCAUCACUU |
| si(T12)-as | GUGAUGAAGAUCACUGUCGUU |
| si(G8)-ss | GUGAUCGGCAUCACCUUGGUU |
| si(G8)-as | CCAAGGUGAUGCCGAUCACUU |
| si(G9)-ss | AGUGAUCGGCAUCACCUUGUU |
| si(G9)-as | CAAGGUGAUGCCGAUCACUUU |
| si(G10)-ss | CAGUGAUCGGCAUCACCUUUU |
| si(G10)-as | AAGGUGAUGCCGAUCACUGUU |
| si(G11)-ss | ACAGUGAUCGGCAUCACCUUU |
| si(G11)-as | AGGUGAUGCCGAUCACUGUUU |
| si(G12)-ss | GACAGUGAUCGGCAUCACCUU |
| si(G12)-as | GGUGAUGCCGAUCACUGUCUU |