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. 2009 Sep;134(3):243–258. doi: 10.1085/jgp.200910255

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© 2009 Liu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 9. — K639 modulates channel conductance and proton inhibition. (A) Unitary current amplitudes of the K639Q mutant versus the wild-type channel at different pHs. The removal of the positive charge caused a reduction of the current amplitudes at all pHs. (B) Ratio of the unitary current amplitudes at each pH to the amplitudes at pH 8.5, showing an increase in the inhibition by protons after charge removal. Single-channel currents were recorded from transiently transfected HEK293 cells in the outside-out configuration. [K⁺] = 1 M, V_h = −60 mV, and data points are means ± SE (n ≥ 5).