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. 2009 Sep;134(3):231–241. doi: 10.1085/jgp.200910272

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© 2009 Beyl et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — Recorded and simulated currents. (A–C) I_Ba through wild-type (A), I781G (B), and I781P (C) channels (left column) during depolarization from −80 mV to the indicated voltages and corresponding current simulations (right column). (D–F) Representative tail currents of wild-type (D), I781G (E), and I781P (F) channels (left column) and corresponding simulations (right column). The fast phase of the tail current (D–F) containing fast (not resolved) components of current deactivation is truncated. The simulated currents were calculated from the full four-state model by solving the ODE system (Eq. 4.5) making use of the estimated rate constants (Tables II and III) and a reversal potential of 48 mV (see also Materials and methods).