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. 2009 Sep;134(3):231–241. doi: 10.1085/jgp.200910272

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© 2009 Beyl et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Voltage dependence of deactivation time constants predicted by fitting the data for mutant I781T to the backward activation pathway: $O ⇄_{}^{} A ⇄_{}^{} R .$ Deactivation time constant (solid line) was calculated by Eq. 2.2 (rate constants are indicated in Tables II and III). The model predicts an increase of the deactivation time constants, whereas the experimentally measured time constants decreased with increasing hyperpolarization (open circles connected by broken line).