TABLE II.
Construct | α | β | γ | δ |
Wild-typea | 0.15 ± 0.11 | 0.24 ± 0.08 | 0.021 ± 0.021 | 1.39 ± 0.17 |
G770P | 0.33 ± 0.31 | 0.31 ± 0.21 | 0.030 ± 0.073 | 0.56 ± 0.11 |
N771Pa | 0.95 ± 0.63 | 0.11 ± 0.07 | 0.111 ± 0.057 | 1.41 ± 0.23 |
F778Pa | 0.13 ± 0.12 | 0.28 ± 0.09 | 0.016 ± 0.026 | 0.70 ± 0.09 |
L779Pa | 1.79 ± 0.81 | 0.11 ± 0.02 | 0.002 ± 0.002 | 0.36 ± 0.09 |
A780Pa | 0.19 ± 0.03 | 0.0064 ± 0.0022 | 0.015 ± 0.005 | 0.14 ± 0.02 |
A780G | 0.96 ± 0.62 | 0.27 ± 0.12 | 0.037 ± 0.022 | 2.10 ± 0.33 |
I781Ta | 1.95 ± 0.91 | 0.045 ± 0.012 | 0.009 ± 0.003 | 1.02 ± 0.26 |
I781Pa | 4.16 ± 1.86 | 0.034 ± 0.007 | 0.003 ± 0.001 | 0.74 ± 0.43 |
I781G | 1.73 ± 0.81 | 0.036 ± 0.010 | 0.011 ± 0.003 | 0.78 ± 0.18 |
I781Aa | 1.72 ± 0.79 | 0.132 ± 0.028 | 0.003 ± 0.001 | 1.55 ± 0.44 |
I781Va | 0.55 ± 0.30 | 0.22 ± 0.03 | 0.0003 ± 0.0002 | 2.01 ± 0.77 |
I781Na | 2.17 ± 0.99 | 0.10 ± 0.02 | 0.003 ± 0.002 | 0.74 ± 0.20 |
A782Pa | 2.65 ± 1.23 | 0.111 ± 0.026 | 0.004 ± 0.002 | 0.94 ± 0.27 |
A782G | 1.74 ± 0.97 | 0.32 ± 0.10 | 0.013 ± 0.009 | 1.96 ± 0.37 |
D784G | 0.88 ± 0.53 | 0.34 ± 0.09 | 0.008 ± 0.006 | 1.62 ± 0.35 |
Rate constants estimated using data from Hohaus et al. (2005).