Table 3.
Genes regulated by estradiol in developing mouse mammary gland and in the estradiol-treated human breast cancer cell line, MCF-7 (Frasor et al. 2004).
| MCF-7 | Mammary gland | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Gene Description | 8h | 48h | 2d | 5d | 7d | 14d | 28d |
| ABCG1 | ATP binding cassette, subfamily G (WHITE), member 1 | 0.35 | 0.47 | - | - | 0.77 | 1.3 | - |
| ADCY9 | Adenylate cyclase 9 | 1.83 | 2.53 | - | - | - | 1.3 | - |
| ALDH4A1 | Aldehyde dehydrogenase 4, member A1 | 0.64 | 0.38 | - | 0.7 | - | - | 0.3 |
| ANXA3 | Annexin A3 | 0.71 | 0.28 | - | 1.3 | 2.3 | 2.4 | 1.7 |
| AREG | Amphiregulin | 6.81 | 7.49 | 4.7 | 5.0 | 11.3 | 6.8 | 10.9 |
| BIK | BCL2-interacting killer | 0.33 | 0.21 | - | - | 1.3 | - | 1.2 |
| CALCR | Calcitonin receptor | 7.45 | 7.91 | 1.8 | - | - | - | - |
| CBX6 | Chromobox homologue 6 | 0.69 | 0.31 | - | - | 1.1 | 1.2 | - |
| CD24 | CD24 antigen | 0.74 | 0.27 | - | - | 1.4 | - | 1.3 |
| CTSH | Cathepsin H | 0.78 | 0.34 | - | 1.5 | - | 1.8 | 1.4 |
| CYP1B1 | Cytochrome P450, Cyp1B1 | 5.23 | 3.17 | 0.63 | 0.73 | 1.5 | - | - |
| DBN1 | Drebrin 1 | 0.69 | 0.36 | - | - | 1.5 | 1.6 | 1.4 |
| DUSP1 | Dual specificity phosphatase 1 | 0.37 | 0.31 | - | - | 0.77 | 0.77 | 0.77 |
| DUSP4 | Dual specificity phosphatase 4 | 0.38 | 0.32 | 1.9 | 2.2 | 1.4 | 1.5 | 2.3 |
| ECH1 | Enoyl Coenzyme A hydratase 1, peroxisomal | 0.67 | 0.29 | - | - | 0.71 | 0.67 | - |
| ENC1 | Ectodermal-neural cortex (with BTB-like domain) | 0.49 | 0.28 | - | - | - | - | 1.2 |
| GNS | Glucosamine (N-acetyl)-6-sulfatase | 0.84 | 0.34 | 1.3 | 1.3 | 1.3 | 1.4 | 1.3 |
| GREB1 | GREB1 protein | 6.14 | 7.61 | 6.1 | 7.6 | 25.3 | 26 | 28 |
| IER3 | Immediate early response 3 | 0.48 | 0.29 | - | 1.4 | 2.0 | 2.4 | 2.4 |
| IFI30 | IFN {gamma}-inducible protein 30 | 0.76 | 0.35 | 1.7 | 1.8 | - | 1.4 | 1.6 |
| IL1R1 | Interleukin 1 receptor, type I | 0.22 | 0.04 | 1.5 | 1.5 | - | 1.4 | 1.6 |
| INHBB | Inhibin, βB | 0.73 | 0.18 | 0.60 | 0.63 | 1.4 | 1.7 | 1.7 |
| IRF6 | IFN regulatory factor 6 | 0.37 | 0.33 | - | - | 2.1 | - | - |
| KRT7 | Keratin 7 | 0.72 | 0.21 | 2.2 | 2.2 | 6.3 | 3.6 | 4.5 |
| LAMB1 | Laminin, β1 | 0.6 | 0.17 | - | 1.4 | 1.6 | 1.6 | 1.4 |
| MATN2 | Matrilin 2 | 0.54 | 0.25 | - | - | 1.2 | - | - |
| MMD | Monocyte to macrophage differentiation-associated | 0.26 | 0.29 | - | - | 0.7 | 0.8 | - |
| PRPS1 | Phosphoribosyl pyrophosphate synthetase 1 | 0.6 | 0.32 | 1.8 | 1.8 | 1.3 | 1.2 | 1.6 |
| PTGES | Prostaglandin E receptor 3 (EP3) | 1.42 | 2.62 | - | 0.60 | 0.63 | 0.59 | 0.67 |
| PVALB | Parvalbumin | 0.66 | 0.13 | 0.69 | 0.46 | 0.37 | 0.37 | 0.37 |
| RAB31 | RAB31 | 7.22 | 4.95 | 1.8 | 1.8 | 1.6 | 2.1 | 2.0 |
| RASGRP1 | RAS guanyl releasing protein 1 | 3.81 | 2.35 | - | - | - | - | 0.63 |
| SDC2 | Syndecan 2 | 2.5 | 2.41 | - | 0.76 | - | - | 0.59 |
| SLIT2 | Slit homologue 2 (Drosophila) | 0.52 | 0.27 | - | - | 3.9 | 1.9 | - |
| SMPD1 | Sphingomyelin phosphodiesterase 1, acid lysosomal | 0.44 | 0.32 | - | - | 0.83 | 0.83 | - |
| SNCG | Synuclein, {gamma} (breast cancer-specific protein 1) | 0.69 | 0.26 | - | - | - | - | 1.6 |
| TGFB2 | Transforming growth factor, β2 | 0.64 | 0.34 | - | - | 1.9 | 2.0 | - |
| TGFB3 | Transforming growth factor, β3 | 0.53 | 0.4 | 1.4 | 1.5 | 2.3 | 1.8 | 1.9 |
| WISP2 | WNT1 inducible signaling pathway protein 2 | 2.39 | 4.9 | 4.5 | 4.1 | 4.2 | 10.9 | 6.2 |