Figure 6.
FGFR1 knockdown reduces anchorage independent growth and growth in vivo. UMUC3 (A) or JMSU1 (B) expressing a non-specific shRNA, shRNA1 or shRNA2 were cultured in soft agar for 21 days and stained with p-iodonitrotretrazolium violet. Graph shows viable colonies greater than 1mm in size per 10cm2. UMUC3 were injected subcutaneously into nude mice and tumor volume measured (C). Solid black line, cells expressing the non-specific control; dashed black line, cells expressing shRNA1; grey line, cells expressing shRNA2. Error bars represent standard error.