Fig. 2.

Schematic representation of the c-kit protein showing the known function of each of its domains. N-T N-terminal; LB ligand binding; DS dimer stabilization; CS cleavage site; TM transmembrane; JM juxtamembrane; TK1 tyrosine kinase domain 1, also known as the proximal kinase domain; KI kinase insert; TK2 tyrosine kinase domain 2 or distal kinase domain; C-T c-terminal domain. Furthermore, after stem cell factor-induced homodimerization, all the tyrosine residues that are phosphorylated and the adaptor proteins that bind to these phosphorylated tyrosine residues also are represented