Inhibition of RhoA attenuates γC-induced endothelial barrier dysfunction and microvascular hyperpermeability. A, siRNA transfection depletes RhoA expression. Lane C, siControl; lanes T1-6, replicates of RhoA siRNA transfection. B, RhoA knockdown attenuates γC-induced TER decrease. *P<0.05 vs. vehicle, #P<0.05 vs. siControl. C, the RhoA kinase inhibitor Y27632 dose-dependently inhibits TER decrease to γC. D, γC-induced albumin leakage in microvasculature is prevented by Y27632 (1 μmol/L, 30 min). *P<0.05 vs. vehicle; #P<0.05 vs. γC only.